Microtubule +TIPs at a glance.
نویسندگان
چکیده
This article is part of a Minifocus on microtubule dynamics. For further reading, please see related articles: ‘Kinesins at a glance’ by Sharyn A. Endow et al., (J. Cell Sci. 123, pp. 3420-3424), ‘Tubulin depolymerization may be an ancient biological motor process’ by J. Richard McIntosh et al. (J. Cell Sci. 123, pp. 3425-3434), ‘Towards a quantitative understanding of mitotic spindle assembly and mechanics’ by Alex Mogilner and Erin Craig (J. Cell Sci. 123, pp. 3435-3445) and ‘Post-translational modifications of microtubules’ by Dorota Wloga and Jacek Gaertig (J. Cell Sci. 123, pp. 3447-3455).
منابع مشابه
Plus-End-Tracking Proteins and Their Interactions at Microtubule Ends
Microtubules are cytoskeletal elements that are essential for a large number of intracellular processes, including mitosis, cell differentiation and migration, and vesicle transport. In many cells, the microtubule network is organized in a radial manner, with one end of a microtubule (the minus end) embedded near the nucleus and the other end (the plus end) exploring cytoplasmic space, switchin...
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The kinesins-8 were originally thought to be microtubule depolymerases, but are now emerging as more versatile catalysts of microtubule dynamics. We show here that S. pombe Klp5-436 and Klp6-440 are non-processive plus-end-directed motors whose in vitro velocities on S. pombe microtubules at 7 and 23 nm s(-1) are too slow to keep pace with the growing tips of dynamic interphase microtubules in ...
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Microtubule plus-end tracking proteins (+TIPs) are structurally and functionally diverse factors that accumulate at the growing microtubule plus-ends, connect them to various cellular structures, and control microtubule dynamics [1, 2]. EB1 and its homologs are +TIPs that can autonomously recognize growing microtubule ends and recruit to them a variety of other proteins. Numerous +TIPs bind to ...
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عنوان ژورنال:
- Journal of cell science
دوره 123 Pt 20 شماره
صفحات -
تاریخ انتشار 2010